Leys, Anita M. and Ramboer, Eva and Favreau, Mérédis and Denhaerynck, Kris and MacDonald, Karen and Abraham, Ivo and Brié, Heidi. (2020) Long-Term Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Belgian Subanalysis from the Global Real-World LUMINOUS TM Study. Clinical ophthalmology, 14. pp. 1473-1481.
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Official URL: https://edoc.unibas.ch/77672/
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Abstract
To evaluate long-term, real-world treatment patterns and outcomes of ranibizumab 0.5 mg for neovascular age-related macular degeneration (nAMD) in a Belgian cohort.; This Belgian (BE) cohort of the 5-year global observational LUMINOUS study included 229 patients with nAMD. Outcomes included visual acuity (VA), central retinal thickness (CRT) and safety.; The mean age was 79.5±7.7 years. The majority of patients (67.7%) were female and all patients were Caucasian. Most patients previously received ranibizumab with only 17.5% of patients being treatment-naïve. The injection frequency declined over time irrespective of prior treatment status (p<0.0001), with treatment-naïve eyes receiving a mean of 4.2±2.9 yearly injections and prior-ranibizumab eyes 3.6±2.7. Regression analysis confirmed first-year VA increases for treatment-naïve eyes (p=0.002) followed by a slight decrease of -1.8 letters per year. For prior-ranibizumab eyes, the visual changes over 1 year were statistically non-significant (p=0.90) but declined slightly after year one (p<0.0001). Anatomically, the CRT of treatment-naïve eyes decreased over time from baseline (p<0.0001), whereas the CRT of prior-ranibizumab eyes remained stable (p=0.43). No new safety findings were identified.; LUMINOUS-BE reconfirms the well-characterized benefit-risk profile of ranibizumab for nAMD treatment. The observed low injection frequency reflects a need for more rigorous treatment in real-world settings.; NCT01318941.
Faculties and Departments: | 03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft |
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UniBasel Contributors: | Denhaerynck, Kris |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Dovepress |
e-ISSN: | 1177-5483 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 07 Jul 2020 08:30 |
Deposited On: | 07 Jul 2020 08:30 |
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