Synthesis of N-Substituted Indoles via Aqueous Ring-Closing Metathesis

Sabatino, Valerio and Staub, Dario and Ward, Thomas R.. (2020) Synthesis of N-Substituted Indoles via Aqueous Ring-Closing Metathesis. Catalysis Letters, ‏151 (1). pp. 17-7.

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We report herein the synthesis of N-substituted indoles resulting from the ring-closing metathesis of indole precursors bearing N-terminal alkenes. The aqueous metathesis of the indole precursors gave good yields of N-substituted indoles (up to 72%) with commercial metathesis catalysts and with artificial metalloenzymes based on the biotin-streptavidin technology. Strikingly, the yield of the N-acetylindole increases in presence of a second metathesis substrate.[GRAPHICS].
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Feb 2021 09:55
Deposited On:16 Feb 2021 09:55

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