Biomolecule-polymer hybrid compartments: combining the best of both worlds

Meyer, Claire E. and Abram, Sarah-Luise and Craciun, Ioana and Palivan, Cornelia G.. (2020) Biomolecule-polymer hybrid compartments: combining the best of both worlds. Physical chemistry chemical physics, 22 (20). pp. 11197-11218.

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Compartmentalization is a fundamental principle in biology that is needed for the temporal and spatial separation of chemically incompatible reactions and biomolecules. Nano- or micro-sized compartments made of synthetic polymers are used to mimick this principle. The self-assembly of these polymers into vesicular objects is highly compatible with the integration of biomolecules, either into the lumen, the membrane or onto the surface of the vesicles. Thus, a great variety of biohybrid nano- and microscaled compartments has been developed exploiting the specific function and properties of targeting peptides, antibodies, enzymes, nucleic acids or lipids. Such biohybrid compartments have moved from simple systems encapsulating e.g. a model protein into complex multicompartmentalized structures that are able to combine the activity of different biomolecular cargos getting closer to the realization of artifical organelles or cells. Encapsulation of medically relevant cargos combined with careful design of the polymeric scaffold and specific surface functionalization have led to a significant progress in therapeutical applications such as targeted drug delivery or enzyme replacement therapy.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Meyer, Claire Elsa and Abram, Sarah-Luise and Craciun, Ioana and Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Royal Society of Chemistry
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:30 Jun 2020 08:33
Deposited On:30 Jun 2020 08:33

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