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A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

Ngabonziza, Jean Claude Semuto and Loiseau, Chloé and Marceau, Michael and Jouet, Agathe and Menardo, Fabrizio and Tzfadia, Oren and Antoine, Rudy and Niyigena, Esdras Belamo and Mulders, Wim and Fissette, Kristina and Diels, Maren and Gaudin, Cyril and Duthoy, Stéphanie and Ssengooba, Willy and André, Emmanuel and Kaswa, Michel K. and Habimana, Yves Mucyo and Brites, Daniela and Affolabi, Dissou and Mazarati, Jean Baptiste and de Jong, Bouke Catherine and Rigouts, Leen and Gagneux, Sebastien and Meehan, Conor Joseph and Supply, Philip. (2020) A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region. Nature Communications, 11. p. 2917.

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Abstract

The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Research (Gagneux)
UniBasel Contributors:Loiseau, Chloé Marie and Menardo, Fabrizio and Brites, Daniela and Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2041-1723
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:17 Jun 2020 10:57
Deposited On:17 Jun 2020 10:57

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