Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease

Walter, Joan and Tanglay, Yunus and du Fay de Lavallaz, Jeanne and Strebel, Ivo and Boeddinghaus, Jasper and Twerenbold, Raphael and Doerflinger, Stephanie and Puelacher, Christian and Nestelberger, Thomas and Wussler, Desiree and Amrein, Melissa and Badertscher, Patrick and Todd, John and Rentsch, Katharina and Fahrni, Gregor and Jeger, Raban and Kaiser, Christoph and Reichlin, Tobias and Mueller, Christian. (2019) Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease. International journal of cardiology, 275. pp. 20-25.

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Official URL: https://edoc.unibas.ch/77024/

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Inflammation plays a major role in the pathogenesis of coronary artery disease (CAD).; We hypothesized, that quantifying inflammation by measuring circulating interleukin-6 concentrations help in the diagnosis and/or prediction of functionally relevant CAD. Among consecutive patients with symptoms suggestive of CAD, functionally relevant CAD was adjudicated in two domains: first, diagnosis according to myocardial perfusion single photon emission tomography (MPI-SPECT) and coronary angiography; second, cardiovascular death and all-cause death during 2-years follow-up. Adjudication was done blinded to the interleukin-6 concentrations.; Among 1553 patients, symptoms were adjudicated to be causally related to CAD in 43% (665/1553). Interleukin-6 concentrations were higher in patients with functionally relevant CAD as compared to those without (1.56 pg/mL versus 1.30 pg/mL, p < 0.001), but overall had only low-to-modest diagnostic accuracy (area under the curve [AUC]: 0.57, 95%CI 0.55-0.61) and were no independent predictor of functionally relevant CAD after multivariable adjustment (p = 0.068). Interleukin-6 concentrations had moderate-to-high accuracy in the prediction of cardiovascular death (AUC 0.75, 95%CI 0.69-0.82) and all-cause death (AUC 0.72, 95%CI 0.66-0.78) at 2-years, and remained a significant predictor after multivariable adjustment (p < 0.001). Compared to patients with interleukin-6 concentrations below the median (1.41 pg/mL), patients with concentrations above the median had a significantly higher cumulative incidence of cardiovascular death (1% vs. 4%, log-rank p < 0.001) and all-cause death (2% vs. 8%, log-rank p < 0.001) at 2 years.; Interleukin-6 concentrations are strong and independent predictors of cardiovascular death and all-cause death.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie > Klinische Outcomeforschung Kardiologie (Müller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie > Klinische Outcomeforschung Kardiologie (Müller)
UniBasel Contributors:Walter, Joan and Müller, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Aug 2020 17:00
Deposited On:18 Aug 2020 17:00

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