edoc

Long-lasting immunity by early infection of maternal-antibody-protected infants

Navarini, Alexander A. and Krzyzowska, Malgorzata and Lang, Karl S. and Horvath, Edit and Hengartner, Hans and Niemialtowski, Marek G. and Zinkernagel, Rolf M.. (2010) Long-lasting immunity by early infection of maternal-antibody-protected infants. European Journal of Immunology, 40 (1). pp. 113-116.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/76818/

Downloads: Statistics Overview

Abstract

Newborn higher vertebrates are largely immuno-incompetent and generally survive infections--including poxviruses--by maternal antibody protection. Here, we show that mice survived epidemics as adults only if exposed to lethal orthopoxvirus infections during infancy under the umbrella of maternal protective antibodies. This implies that both the absence of exposure to infection during early infancy or of effective vaccination renders the population highly susceptible to new or old re-emerging pathogens.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0014-2980
e-ISSN:1521-4141
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:01 Oct 2020 06:46
Deposited On:01 Oct 2020 06:46

Repository Staff Only: item control page