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Safety of the current drug treatments for vitiligo

Lotti, Torello and Agarwal, Komal and Podder, Indrashis and Satolli, Francesca and Kassir, Martin and Schwartz, Robert A. and Wollina, Uwe and Grabbe, Stephan and Navarini, Alexander A. and Mueller, Simon M. and Goldust, Mohamad. (2020) Safety of the current drug treatments for vitiligo. Expert Opinion on Drug Safety , 19 (4). pp. 499-511.

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Official URL: https://edoc.unibas.ch/76714/

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Abstract

Introduction; : Vitiligo is an acquired depigmenting skin disorder adversely affecting the patient's quality of life. Despite the presence of several treatment modalities, ranging from medical to physical to surgical options, none is curative. Each modality has its own drawbacks and side effects. Thus, the treatment modality needs to be tailored for each individual patient taking into consideration the disease characteristics and also its efficacy and safety to obtain a favorable risk-benefit ratio.; Areas covered; : This review highlights the different treatment modalities utilized in vitiligo up until 4 November 2019 along with their adverse effects and contraindications, if any.; Expert opinion; : All the medications have their own adverse effects and contraindications. We have included the most commonly used topical corticosteroids, which may result in striae, cutaneous atrophy, and tachyphylaxis, to the recently introduced biologics, which may induce hypersensitivity reactions, systemic toxicities, and even malignancies. However, more long-term studies are needed to assess the safety of these medications, especially the newer ones, to provide a safe and effective treatment for this disorder.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor & Francis
ISSN:1474-0338
e-ISSN:1744-764X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Dec 2020 15:30
Deposited On:29 Dec 2020 15:30

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