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Pain Reduction by Dehydrated Human Amnion/chorion Membrane Allograft in Non-diabetic Leg Ulcers Might be an Early Indicator of Good Response: A Case Series

Mueller, Simon M. and Navarini, Alexander A. and Itin, Peter and Schwegler, Simon and Laeuchli, Severin and Goldust, Mohamad and Ivanova, Katja. (2020) Pain Reduction by Dehydrated Human Amnion/chorion Membrane Allograft in Non-diabetic Leg Ulcers Might be an Early Indicator of Good Response: A Case Series. Dermatologic Therapy, 33 (4). e13587.

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Official URL: https://edoc.unibas.ch/76701/

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Abstract

Dehydrated human amnion/chorion membrane allograft (dHACM) derived from placenta is increasingly used for skin and soft tissue repair in several medical specialties. Promising effects of dHACM were also reported in chronic venous and diabetic leg ulcers. However, dHACM is cost-intensive and its effect on chronic leg ulcers of other etiologies and pain reduction is unknown. Clinical predictors of a favorable response to dHACM during the early treatment period could help to limit unnecessary costs. In our case series with six patients suffering from chronic lower leg ulcers of various etiology, the effect of dHACM once per week on reduction of pain and wound size during a 5-week period was examined. dHACM resulted in effective pain reduction and improved wound healing in three patients with chronic leg ulcers due to calciphylaxis, chronic venous disease and reactive angioendotheliomatosis. Pain reduction after 1 to 2 applications of dHACM predicted a favorable healing response. Hence, our observation indicates that assessment of pain 3 weeks after initiation of dHACM may be a clinical predictor to justify dis-/continuation of dHACM and thereby may help to limit costs.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1396-0296
e-ISSN:1529-8019
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:29 Dec 2020 15:36
Deposited On:29 Dec 2020 15:36

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