The prion protein is neuroprotective against retinal degeneration in vivo

Frigg, Rico and Wenzel, Andreas and Samardzija, Marijana and Oesch, Bruno and Wariwoda, Hedwig and Navarini, Alexander A. and Seeliger, Mathias W. and Tanimoto, Naoyuki and Remé, Charlotte and Grimm, Christian. (2006) The prion protein is neuroprotective against retinal degeneration in vivo. Experimental eye research, 83 (6). pp. 1350-1358.

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A common feature of neurodegenerative disorders is acute or progressive loss of neurons due to apoptosis. The pathological isoform of the prion protein is associated with retinal apoptosis and the cellular isoform (PrPc) has been shown to mediate protection from apoptosis in cell culture and in neonatal retinal explants. Using a model of light-induced photoreceptor apoptosis, we show in vivo that the levels of PrPc expression in the retina inversely correlate with the susceptibility of photoreceptors to light damage. Dissection of apoptotic signalling cascades suggests that PrPc acts neuroprotectively downstream of AP-1 induction. Our results reveal PrP as a neuroprotective/anti-apoptotic factor in vivo and suggest that PrPc may function as a guardian of neuronal integrity.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Academic Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Sep 2020 11:14
Deposited On:30 Sep 2020 11:14

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