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Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses

Navarini, Alexander A. and Recher, Mike and Lang, Karl S. and Georgiev, Panco and Meury, Susanne and Bergthaler, Andreas and Flatz, Lukas and Bille, Jacques and Landmann, Regine and Odermatt, Bernhard and Hengartner, Hans and Zinkernagel, Rolf M.. (2006) Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proceedings of the National Academy of Sciences of the United States of America, 103 (42). pp. 15535-15539.

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Official URL: https://edoc.unibas.ch/76690/

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Abstract

The reason why severe localized or systemic virus infections enhance and aggravate bacterial superinfection is poorly understood. Here we show that virus-induced IFN type I caused apoptosis in bone marrow granulocytes, drastically reduced granulocyte infiltrates at the site of bacterial superinfection, caused up to 1,000-fold higher bacterial titers in solid organs, and increased disease susceptibility. The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Academy of Sciences
ISSN:0027-8424
e-ISSN:1091-6490
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Sep 2020 11:04
Deposited On:30 Sep 2020 11:04

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