Treating treatment non-responders: A meta-analysis of randomized controlled psychotherapy trials

Gloster, Andrew T. and Rinner, Marcia T. B. and Ioannou, Myria and Villanueva, Jeanette and Block, Victoria J. and Ferrari, Giovanna and Benoy, Charles and Bader, Klaus and Karekla, Maria. (2020) Treating treatment non-responders: A meta-analysis of randomized controlled psychotherapy trials. Clinical Psychology Review, 75. p. 101810.

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Official URL: https://edoc.unibas.ch/76569/

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Background: Non-responsiveness to treatment occurs in approximately one third of patients. Randomized clinical trials of psychotherapy options for these patients are scarce and systematic knowledge about whether psychotherapy is a viable option is lacking.Objectives: This meta-analysis aimed to 1) determine the amount of evidence available for treatment non-response using psychotherapy relative to pharmacological procedures; 2) systematically review randomized controlled psychotherapy trials (RCTs) used to treat non-responders; and 3) examine whether some psychotherapies are more efficacious than others.Data sources: Online databases were systematically examined and references of relevant systematic reviews were hand-searched.Study eligibility criteria: RCTs that administered a psychotherapy new to non-responders were considered. All Mood and Anxiety Disorders were considered. No limitations were made with respect to type of treatment.Review method: A meta-analytic review of the psychotherapy RCTs for treatment non-responders.Results: Results showed that psychotherapy was successful in treating treatment non-responders with a medium to large effect size. Between-group comparisons did not reveal significant differences in treatment effects for any of the assessed disorder or treatment types. Effects were maintained at follow-up.Conclusions: Psychotherapy is a viable treatment option for treatment non-responders. More attention to this group of patients is needed and more research with better quality studies is warranted. Recommendations are discussed.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Clinical Psychology and Intervention Science (Gloster)
UniBasel Contributors:Gloster, Andrew
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:01 Jan 2022 02:30
Deposited On:11 May 2020 12:05

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