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Antibiotic chemotherapy against heterogeneous pathogen populations in complex host tissues

Bumann, Dirk and Fanous, Joseph and Li, Jiagui and Goormaghtigh, Frédéric. (2019) Antibiotic chemotherapy against heterogeneous pathogen populations in complex host tissues. F1000Research, 8. p. 1781.

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Official URL: https://edoc.unibas.ch/76513/

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Abstract

Antibiotic chemotherapy effectively cures many infections caused by susceptible bacterial pathogens. However, in some cases, even extended treatment duration does not completely eradicate the pathogenic bacteria from host tissues. A common model for underlying mechanisms assumes the stochastic formation of bacterial persisters similar to observations in laboratory cultures. However, alternative explanations related to the complexity of infected host tissues could also be relevant. We discuss several of these aspects and emphasize the need for integrated analysis as a basis for new control strategies.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk and Fanous, Joseph and Li, Jiagui and Goormaghtigh, Frédéric
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:F1000Research
ISSN:2046-1402
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:30 Apr 2020 14:11
Deposited On:30 Apr 2020 14:11

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