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Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

Burte, Emilie and Leynaert, Bénédicte and Marcon, Alessandro and Bousquet, Jean and Benmerad, Meriem and Bono, Roberto and Carsin, Anne-Elie and de Hoogh, Kees and Forsberg, Bertil and Gormand, Frederic and Heinrich, Joachim and Just, Jocelyne and Nieuwenhuijsen, Mark and Pin, Isabelle and Stempfelet, Morgane and Sunyer, Jordi and Villani, Simona and Künzli, Nino and Siroux, Valérie and Jarvis, Deborah and Nadif, Rachel and Jacquemin, Bénédicte. (2020) Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts. Journal of allergy and clinical immunology, 145 (3). pp. 834-842.e6.

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Official URL: https://edoc.unibas.ch/76134/

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Abstract

Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults.; We sought to assess the cross-sectional association between individual long-term exposure to air pollution and severity of rhinitis.; Participants with rhinitis from 2 multicenter European cohorts (Epidemiological Study on the Genetics and Environment on Asthma and the European Community Respiratory Health Survey) were included. Annual exposure to NO; 2; , PM; 10; , PM; 2.5; , and PM; coarse; (calculated by subtracting PM; 2.5; from PM; 10; ) was estimated using land-use regression models derived from the European Study of Cohorts for Air Pollution Effects project, at the participants' residential address. The score of rhinitis severity (range, 0-12), based on intensity of disturbance due to symptoms reported by questionnaire, was categorized into low (reference), mild, moderate, and high severity. Polytomous logistic regression models with a random intercept for city were used.; A total of 1408 adults with rhinitis (mean age, 52 years; 46% men, 81% from the European Community Respiratory Health Survey) were included. The median (1st quartile-3rd quartile) score of rhinitis severity was 4 (2-6). Higher exposure to PM; 10; was associated with higher rhinitis severity (adjusted odds ratio [95% CI] for a 10 μg/m; 3; increase in PM; 10; : for mild: 1.20 [0.88-1.64], moderate: 1.53 [1.07-2.19], and high severity: 1.72 [1.23-2.41]). Similar results were found for PM; 2.5; . Higher exposure to NO; 2; was associated with an increased severity of rhinitis, with similar adjusted odds ratios whatever the level of severity. Adjusted odds ratios were higher among participants without allergic sensitization than among those with, but interaction was found only for NO; 2.; CONCLUSIONS: People with rhinitis who live in areas with higher levels of pollution are more likely to report more severe nasal symptoms. Further work is required to elucidate the mechanisms of this association.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:de Hoogh, Kees and Künzli, Nino
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Mosby
ISSN:0091-6749
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Mar 2020 08:53
Deposited On:27 Mar 2020 08:53

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