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Antimalarial drug concentrations in the blood : a monitoring tool for evaluating population drug usage in relation to diagnosis and treatment environment

Gallay, Joanna. Antimalarial drug concentrations in the blood : a monitoring tool for evaluating population drug usage in relation to diagnosis and treatment environment. 2018, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_13564

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Abstract

Malaria case management using malaria rapid diagnosis tests (mRDTs) and artemisinin-based combinations therapies (ACTs), the only effective and widely used antimalarial treatment, is a key intervention to control malaria. In Tanzania, case management policies require parasitological confirmation of malaria prior to treatment for patients of all ages. To that aim, considerable efforts have been made to improve diagnosis availability and compliance to diagnosis results and to expand access to effective antimalarials in the public and private sector. Despite that, there are concerns that treatments are not always targeted to those in need.
The impact of new diagnosis or treatment strategies on drug use has previously been evaluated by longitudinal recording of HF drugs stocks and/or their prescription rates in intervention and control areas, or before and after an intervention implementation. Alternatively, information on recent history of fever, diagnosis and drug intake was gathered through community surveys. But the biases potentially affecting these measured are numerous and these study might therefore not reflect accurately the amount of drugs circulating among the population. This latter variable is probably the most important determinant to the development of pathogen resistance to drugs.
To address this issue of public health relevance, we used a community-based approach to test the usefulness of measuring concentrations of antimalarial drugs in the blood. This tool was used to monitor population drug use and study the relationships between factors such as malaria prevalence, diagnosis and treatment practices, drug pressure and drug resistance.
Advisors:Utzinger, Jürg and Genton, Blaise and Goodman, Catherine
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Health Impact Assessment (Utzinger)
UniBasel Contributors:Genton, Blaise
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:13564
Thesis status:Complete
Number of Pages:1 Online-Ressource (XVI, 190 Seiten)
Language:English
Identification Number:
Last Modified:09 Jun 2020 04:30
Deposited On:08 Jun 2020 11:50

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