Cyclic Peptides as Inhibitors of Amyloid Fibrillation

Luo, Jinghui and Abrahams, Jan Pieter. (2014) Cyclic Peptides as Inhibitors of Amyloid Fibrillation. Chemistry - A European Journal, 20 (9). pp. 2410-2419.

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Official URL: https://edoc.unibas.ch/75907/

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Many neurodegenerative diseases, like Parkinson's, Alzheimer's, or Huntington's disease, occur as a result of amyloid protein fibril formation and cell death induced by this process. Cyclic peptides (CPs) and their derivatives form a new class of powerful inhibitors that prevent amyloid fibrillation and decrease the cytotoxicity of aggregates. The strategies for designing CPs are described, with respect to their amino acid sequence and/or conformational similarity to amyloid fibrils. The implications of CPs for the study and possible treatment of amyloid-related diseases are discussed.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nano-diffraction of Biological Specimen (Abrahams)
UniBasel Contributors:Abrahams, Jan Pieter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 Jun 2020 12:58
Deposited On:24 Jun 2020 12:58

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