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New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

Guerrero-Ferreira, Ricardo and Kovacik, Lubomir and Ni, Dongchun and Stahlberg, Henning. (2020) New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy. Current Opinion in Neurobiology, 61. pp. 89-95.

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Official URL: https://edoc.unibas.ch/75795/

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Abstract

Fibrils of alpha-synuclein are significant components of cellular inclusions associated with several neuropathological disorders including Parkinson's disease, multiple system atrophy and dementia with Lewy bodies. In recent years, technological advances in the field of transmission electron microscopy and image processing have made it possible to solve the structure of alpha-synuclein fibrils at high resolution. This review discusses the results of structural studies using cryo-electron microscopy, which revealed that in-vitro produced fibrils vary in diameter from 5nm for single-protofilament fibrils, to 10nm for two-protofilament fibrils. In addition, the atomic models hint at contributions of the familial Parkinson's disease mutation sites to inter-protofilament interaction and the locations where post-translational modifications take place. Here, we propose a nomenclature system that allows identifying the existing alpha-synuclein polymorphs and that will allow to incorporate additional high-resolution structures determined in the future.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Stahlberg)
UniBasel Contributors:Stahlberg, Henning
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0959-4388
e-ISSN:1873-6882
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Nov 2021 16:37
Deposited On:23 Nov 2021 16:37

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