The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-β (Aβ) Peptide at the Oligomeric Stage

Wallin, Cecilia and Hiruma, Yoshitaka and Wärmländer, Sebastian K. T. S. and Huvent, Isabelle and Jarvet, Jüri and Abrahams, Jan Pieter and Gräslund, Astrid and Lippens, Guy and Luo, Jinghui. (2018) The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-β (Aβ) Peptide at the Oligomeric Stage. Journal of the American Chemical Society. pp. 8138-8146.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/75788/

Downloads: Statistics Overview


In Alzheimer's disease, amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the two pathological hallmarks. The co-occurrence and combined reciprocal pathological effects of Aβ and tau protein aggregation have been observed in animal models of the disease. However, the molecular mechanism of their interaction remain unknown. Using a variety of biophysical measurements, we here show that the native full-length tau protein solubilizes the Aβ; 40; peptide and prevents its fibrillation. The tau protein delays the amyloid fibrillation of the Aβ; 40; peptide at substoichiometric ratios, showing different binding affinities toward the different stages of the aggregated Aβ; 40; peptides. The Aβ monomer structure remains random coil in the presence of tau, as observed by nuclear magnetic resonance (NMR), circular dichroism (CD) spectroscopy and photoinduced cross-linking methods. We propose a potential interaction mechanism for the influence of tau on Aβ fibrillation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nano-diffraction of Biological Specimen (Abrahams)
UniBasel Contributors:Abrahams, Jan Pieter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:28 Mar 2020 14:24
Deposited On:28 Mar 2020 14:24

Repository Staff Only: item control page