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Impact of Green Tea Catechin ECG and Its Synthesized Fluorinated Analogue on Prostate Cancer Cells and Stimulated Immunocompetent Cells

Stadlbauer, Sven and Steinborn, Carmen and Klemd, Amy and Hattori, Fumihiko and Ohmori, Ken and Suzuki, Keisuke and Huber, Roman and Wolf, Philipp and Gründemann, Carsten. (2018) Impact of Green Tea Catechin ECG and Its Synthesized Fluorinated Analogue on Prostate Cancer Cells and Stimulated Immunocompetent Cells. Planta medica, 84 (11). pp. 813-819.

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Official URL: https://edoc.unibas.ch/75702/

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Abstract

Among the known or suspected risk factors, inflammation plays an important role in infectious and non-infectious pathways leading to cancer. Green tea polyphenols have been associated with reducing inflammation and protection against carcinogenesis, especially in prostate cancer. While most of the research in this field, so far, has focussed on epigallocatechin-3-; O; -gallate only, we studied epicatechin-3-; O; -gallate, the second most abundant green tea polyphenol with essential therapeutic potential, to obtain a more detailed understanding of its anti-tumor and anti-inflammatory action. Furthermore, to improve the bioactivity of (-)-epicatechin-3-; O; -gallate, we synthesized a difluoro analogue, called (-)-5,7-difluoro-epicatechin-3-; O; -gallate. Both compounds reduced cell proliferation of human primary inflammatory lymphocytes in an apoptosis-specific fashion, while (-)-5,7-difluoro-epicatechin-3-; O; -gallate had a significantly higher activity compared to the natural product (-)-epicatechin-3-; O; -gallate. Treatment of low-metastatic LNCaP and high-metastatic PC-3 prostate cancer cells with (-)-epicatechin-3-; O; -gallate and (-)-5,7-difluoro-epicatechin-3-; O; -gallate demonstrated a dose-dependent inhibition of cell viability in the low micromolar range. These effects suggest that (-)-epicatechin-3-; O; -gallate and the more effective (-)-5,7-difluoro-epicatechin-3-; O; -gallate could be therapeutically used to inhibit tumorigenesis during initiation, promotion, and progression by diminishing the amount of inflammation due to a reduction of inflammatory lymphocytes. Further studies are needed to prove this in; in vivo; experiments.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Translationale Komplementärmedizin (Gründemann)
UniBasel Contributors:Gründemann, Carsten
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1439-0221
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Mar 2020 14:55
Deposited On:28 Mar 2020 14:55

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