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Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants

Lederer, Ann-Kathrin and Hannibal, Luciana and Hettich, Manuel and Behringer, Sidney and Spiekerkoetter, Ute and Steinborn, Carmen and Gründemann, Carsten and Zimmermann-Klemd, Amy Marisa and Müller, Alexander and Simmet, Thomas and Schmiech, Michael and Maul-Pavicic, Andrea and Samstag, Yvonne and Huber, Roman. (2019) Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants. Nutrients, 11 (11). p. 2815.

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Official URL: https://edoc.unibas.ch/75696/

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Abstract

Vegans are at an increased risk for certain micronutrient deficiencies, foremost of vitamin B; 12; . Little is known about the short-term effects of dietary change to plant-based nutrition on vitamin B; 12; metabolism. Systemic biomarkers of vitamin B; 12; status, namely, serum vitamin B; 12; and holotranscobalamin, may respond quickly to a reduced intake of vitamin B; 12; . To test this hypothesis, 53 healthy omnivore subjects were randomized to a controlled unsupplemented vegan diet (VD,; n; = 26) or meat-rich diet (MD,; n; = 27) for 4 weeks. Vitamin B; 12; status was examined by measurement of serum vitamin B; 12; , holotranscobalamin (holo-TC), methylmalonic acid (MMA) and total plasma homocysteine (tHcy). Holo-TC decreased significantly in the VD compared to the MD group after four weeks of intervention, whereas metabolites MMA and tHcy were unaffected. Body weight remained stable in both groups. VD intervention led to a significant reduction of cholesterol intake, and adequate profiles of nutrient and micronutrient status. Lower intake of vitamin B; 12; was observed in VD, which was mirrored by a lower concentration of serum vitamin B; 12; and reduced holo-TC after 4 weeks. Plasma holo-TC may be a fast-responding biomarker to monitor adequate supply of vitamin B; 12; in plant-based individuals.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Translationale Komplementärmedizin (Gründemann)
UniBasel Contributors:Gründemann, Carsten
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2072-6643
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Mar 2020 12:03
Deposited On:30 Mar 2020 12:03

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