Plucinski, Mateusz M. and Candrinho, Baltazar and Dimene, Mercia and Smith, Tom and Thwing, Julie and Colborn, James and Rogier, Eric and Zulliger, Rose. (2020) Estimation of malaria-attributable fever in malaria test-positive febrile outpatients in three provinces of Mozambique, 2018. American journal of tropical medicine and hygiene, 102 (1). pp. 151-155.
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Official URL: https://edoc.unibas.ch/75674/
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Abstract
Like most malaria-endemic countries, Mozambique relies on tabulation of confirmed malaria test-positive febrile patients to track incidence of malaria. However, this approach is potentially biased by incidental malaria parasitemia in patients with fever of another etiology. We compared pan-; Plasmodium; aldolase and lactate dehydrogenase and; Plasmodium falciparum; histidine-rich protein 2 (PfHRP2) antigen concentrations measured using a laboratory bead-based assay of samples collected from 1,712 febrile and afebrile patients of all ages in Maputo, Zambézia, and Cabo Delgado provinces. We used a Bayesian latent class model to estimate the proportion of malaria-attributable fevers in malaria test-positive febrile patients. Depending on the antigen, estimated rates of malaria-attributable fever in malaria test-positive febrile patients were 100% in Maputo, 33-58% in Zambézia, and 63-74% in Cabo Delgado. Our findings indicate that most malaria test-positive febrile patients in the three provinces of Mozambique had a fever that was likely caused by the concurrent malaria infection. Counting malaria test-positive febrile patients for estimation of malaria incidence appears to be appropriate in this setting.
Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Infectious Disease Modelling > Epidemiology and Transmission Dynamics (Smith) |
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UniBasel Contributors: | Smith, Thomas A. |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Williams and Wilkins |
ISSN: | 0002-9637 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 05 Mar 2020 12:53 |
Deposited On: | 05 Mar 2020 12:53 |
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