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Estimation of malaria-attributable fever in malaria test-positive febrile outpatients in three provinces of Mozambique, 2018

Plucinski, Mateusz M. and Candrinho, Baltazar and Dimene, Mercia and Smith, Tom and Thwing, Julie and Colborn, James and Rogier, Eric and Zulliger, Rose. (2020) Estimation of malaria-attributable fever in malaria test-positive febrile outpatients in three provinces of Mozambique, 2018. American journal of tropical medicine and hygiene, 102 (1). pp. 151-155.

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Official URL: https://edoc.unibas.ch/75674/

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Abstract

Like most malaria-endemic countries, Mozambique relies on tabulation of confirmed malaria test-positive febrile patients to track incidence of malaria. However, this approach is potentially biased by incidental malaria parasitemia in patients with fever of another etiology. We compared pan-; Plasmodium; aldolase and lactate dehydrogenase and; Plasmodium falciparum; histidine-rich protein 2 (PfHRP2) antigen concentrations measured using a laboratory bead-based assay of samples collected from 1,712 febrile and afebrile patients of all ages in Maputo, Zambézia, and Cabo Delgado provinces. We used a Bayesian latent class model to estimate the proportion of malaria-attributable fevers in malaria test-positive febrile patients. Depending on the antigen, estimated rates of malaria-attributable fever in malaria test-positive febrile patients were 100% in Maputo, 33-58% in Zambézia, and 63-74% in Cabo Delgado. Our findings indicate that most malaria test-positive febrile patients in the three provinces of Mozambique had a fever that was likely caused by the concurrent malaria infection. Counting malaria test-positive febrile patients for estimation of malaria incidence appears to be appropriate in this setting.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Infectious Disease Modelling > Epidemiology and Transmission Dynamics (Smith)
UniBasel Contributors:Smith, Thomas A.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Mar 2020 12:53
Deposited On:05 Mar 2020 12:53

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