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Setting our sights on infectious diseases

De Rycker, Manu and Horn, David and Aldridge, Bree and Amewu, Richard K. and Barry, Clifton E. and Buckner, Frederick S. and Cook, Sarah and Ferguson, Michael A. J. and Gobeau, Nathalie and Herrmann, Jennifer and Herrling, Paul and Hope, William and Keiser, Jennifer and Lafuente-Monasterio, Maria Jose and Leeson, Paul D. and Leroy, Didier and Manjunatha, Ujjini H. and McCarthy, James and Miles, Timothy J. and Mizrahi, Valerie and Moshynets, Olena and Niles, Jacquin and Overington, John P. and Pottage, John and Rao, Srinivasa P. S. and Read, Kevin D. and Ribeiro, Isabela and Silver, Lynn L. and Southern, Jen and Spangenberg, Thomas and Sundar, Shyam and Taylor, Caitlin and Van Voorhis, Wes and White, Nicholas J. and Wyllie, Susan and Wyatt, Paul G. and Gilbert, Ian H.. (2020) Setting our sights on infectious diseases. ACS infectious diseases, 6 (1). pp. 3-13.

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Abstract

In May 2019, the Wellcome Centre for Anti-Infectives Research (; W; CAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Helminth Drug Development (Keiser)
UniBasel Contributors:Keiser, Jennifer
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:ACS Publications
ISSN:2373-8227
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:05 Mar 2020 12:48
Deposited On:05 Mar 2020 12:48

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