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Real-Time Breath Analysis Reveals Specific Metabolic Signatures of COPD Exacerbations

Gaugg, Martin Thomas and Nussbaumer-Ochsner, Yvonne and Bregy, Lukas and Engler, Anna and Stebler, Nina and Gaisl, Thomas and Bruderer, Tobias and Nowak, Nora and Sinues, Pablo and Zenobi, Renato and Kohler, Malcolm. (2019) Real-Time Breath Analysis Reveals Specific Metabolic Signatures of COPD Exacerbations. Chest, 156 (2). pp. 269-276.

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Official URL: https://edoc.unibas.ch/75576/

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Abstract

Exacerbations of COPD are defined by acute worsening of respiratory symptoms leading to a change in therapy. Identifying altered metabolic processes in patients at risk for future exacerbations is desirable for treatment optimization, the development of new therapeutic strategies, and perhaps diagnostic value. We aimed to identify affected pathways using the profiles of volatile organic compounds in exhaled breath from patients with COPD with and without frequent exacerbations (≥ 2 exacerbations within the past 12 months).; In this matched cohort study, exhaled breath profiles from patients with COPD and frequent exacerbations ("frequent exacerbators") and without frequent exacerbations ("nonfrequent exacerbators") were analyzed during an exacerbation-free interval using real-time secondary electrospray ionization high-resolution mass spectrometry. We analyzed exhaled breath from 26 frequent exacerbators and 26 nonfrequent exacerbators that were matched in terms of age, sex, and smoking history. To obtain new pathophysiological insights, we investigated significantly altered metabolites, which can be assigned to specific pathways. Metabolites were identified by using a Wilcoxon rank-sum test.; Metabolite levels from the ω-oxidation pathway, namely ω-hydroxy, ω-oxo, and dicarboxylic acids, were consistently decreased in frequent exacerbators. Additionally, several new nitro-aromatic metabolites, which were significantly increased in frequent exacerbators, were identified.; Real-time breath analysis by secondary electrospray high-resolution mass spectrometry allows molecular profiling of exhaled breath, providing insights about ongoing biochemical processes in patients with COPD at risk for exacerbations.; ClinicalTrials.gov; No.: NCT02186639; URL: www.clinicaltrials.gov.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedical Engineering > Imaging and Computational Modelling > Translational Medicine Breath Research (Sinues)
UniBasel Contributors:Sinues, Pablo
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1931-3543
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Mar 2020 12:08
Deposited On:30 Mar 2020 12:08

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