Moderators of Treatment Efficacy in Individualized Metacognitive Training for Psychosis (MCT+)

Leanza, Letizia and Studerus, Erich and Bozikas, Vasilis P. and Moritz, Steffen and Andreou, Christina. (2020) Moderators of Treatment Efficacy in Individualized Metacognitive Training for Psychosis (MCT+). Journal of Behavior Therapy and Experimental Psychiatry, 68. p. 101547.

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Official URL: https://edoc.unibas.ch/75160/

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Individualized Metacognitive Training (MCT+) is a manualized intervention designed to improve delusional severity by reducing delusion-associated cognitive biases such as jumping-to-conclusions. Increased interest in personalized medicine stipulates the identification of patients who are more likely to benefit from specialized interventions. The present study aimed to explore baseline moderators of MCT+ efficacy on delusions and overall positive symptoms in psychosis.; We analyzed data from a randomized rater-blind controlled trial, in which 92 patients with psychotic disorders and current or past delusions were randomly assigned to either MCT+ or CogPack®, a cognitive remediation software. Baseline moderator variables consisted of jumping-to-conclusions, cognitive insight, quality of life, self-esteem, selective attention, and patients' attitudes towards their symptoms. Linear mixed-effects models were applied to investigate specific moderators of MCT+ efficacy.; In MCT+ relative to CogPack, presence of a jumping-to-conclusions bias, a lowered decision threshold, and low self-esteem were associated with larger improvements in delusional severity and/or overall positive symptoms over time. Subjective reasoning style and insight, as well as subjective attitudes towards psychosis, did not moderate the treatment efficacy of MCT+ relative to CogPack.; Participation of both treatment groups in group MCT as a part of standard care, possibly leading to additional effects on delusional severity.; Patients with low self-esteem and those who are prone to jumping-to-conclusions seem to particularly benefit from MCT+. Our results can help inform clinical practice as they provide specific criteria for selecting patients for whom MCT+ is most appropriate.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Society & Choice > Entwicklungs- und Persönlichkeitspsychologie (Grob)
UniBasel Contributors:Studerus, Erich and Brändli-Leanza, Letizia
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Mar 2021 08:49
Deposited On:04 Jan 2021 08:05

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