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A weighted genetic risk score of adult glioma susceptibility loci associated with pediatric brain tumor risk

Adel Fahmideh, Maral and Lavebratt, Catharina and Tettamanti, Giorgio and Schüz, Joachim and Röösli, Martin and Kjaerheim, Kristina and Grotzer, Michael A. and Johansen, Christoffer and Kuehni, Claudia E. and Lannering, Birgitta and Schmidt, Lisbeth S. and Darabi, Hatef and Feychting, Maria. (2019) A weighted genetic risk score of adult glioma susceptibility loci associated with pediatric brain tumor risk. Scientific reports, 9. p. 18142.

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Abstract

Genetic risk score (GRS) is used to demonstrate the genetic variants contributing to the polygenic architecture of complex diseases. By using a GRS, we have investigated the additive impact of the known adult glioma susceptibility loci on the pediatric brain tumor (PBT) risk and assessed the proportion of PBT heritability attributable to these susceptibility loci. A GRS was generated for PBTs based on the alleles and associated effect sizes derived from a previously published genome-wide association study on adult glioma. The GRS was calculated in CEFALO, a population-based case-control study of brain tumors in children and adolescents including saliva DNA of 245 cases and 489 controls. The unconditional logistic regression model was used to investigate the association between standardized GRS and risk of PBTs. To measure the variance explained by the effect of GRS, Nagelkerke pseudo-R; 2; was calculated. The GRS for adult brain tumors was associated with an increased risk of PBTs (OR 1.25 [95% CI 1.06-1.49], p = 0.009) and 0.3% of the variance in PBTs could be explained by the effect of GRS on the liability scale. This study provides evidence that heritable risks of PBTs are in-part attributable to some common genetic variants associated with adult glioma.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Röösli, Martin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Nature
ISSN:0169-5487
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
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Last Modified:05 Mar 2020 07:59
Deposited On:05 Mar 2020 07:59

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