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A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

Moon, Ho-Sang and Jacobson, Eric M. and Khersonsky, Sonya M. and Luzung, Michael R. and Walsh, Daniel P. and Xiong, Wennan and Lee, Jae Wook and Parikh, Puja B. and Lam, Jennifer C. and Kang, Tae-Wook and Rosania, Gustavo R. and Schier, Alexander F. and Chang, Young-Tae. (2002) A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. Journal of the American Chemical Society, 124 (39). pp. 11608-11609.

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Official URL: https://edoc.unibas.ch/74889/

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Abstract

The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:0002-7863
e-ISSN:1520-5126
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:06 Nov 2020 13:05
Deposited On:06 Nov 2020 13:05

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