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Skin Transplantation and Lymphoid Organ Analysis in Mice

Ruer-Laventie, Julie and Jayachandran, Rajesh and Schmaler, Mathias and Rossi, Simona W. and Pieters, Jean. (2020) Skin Transplantation and Lymphoid Organ Analysis in Mice. Bio-protocol, 10 (4). e3531.

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Official URL: https://edoc.unibas.ch/74804/

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Abstract

Skin transplantation in mice is an important procedure to evaluate immune responses generated against heterologous grafts, especially given its highly immunogenic nature. In fact, skin is one of the most challenging organs in terms of allograft retention. In this protocol, we provide a detailed procedure for skin grafting using the tail skin as donor organ that is grafted on the dorsal site of thoracic cage in a recipient mouse. We also provide protocols for the systematic analysis of lymphoid organ analysis in transplanted mice. Together these protocols may be valuable for evaluation of parameters that affect skin grafting, including genetic factors, immune cell activation as well as the analysis of compounds that may be useful in allowing graft tolerance.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Bio-Protocol
e-ISSN:2331-8325
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:20 Oct 2021 14:47
Deposited On:20 Oct 2021 14:47

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