Jayachandran, Rajesh and Pieters, Jean. (2020) Induction of allograft tolerance while maintaining immunity against microbial pathogens: does coronin 1 hold a key? Transplantation, 104 (7). pp. 1350-1357.
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Abstract
Selective suppression of graft rejection while maintaining anti-pathogen responses has been elusive. Thus far, the most successful strategies to induce suppression of graft rejection relies on inhibition of T cell activation. However, the very same mechanisms that induce allograft-specific T cell suppression are also important for immunity against microbial pathogens as well as oncogenically transformed cells, resulting in significant immunosuppression-associated comorbidities. Therefore, defining the pathways that differentially regulate anti-graft versus anti-microbial T cell responses may allow the development of regimen to induce allograft-specific tolerance. Recent work has defined a molecular pathway driven by the immunoregulatory protein coronin 1 that regulates the phosphodiesterase/cAMP pathway and modulates T cell responses. Interestingly, disruption of coronin 1 promotes allograft tolerance while immunity towards a range of pathogenic microbes is maintained. Here, we briefly review the work leading up to these findings as well as their possible implications for transplantation medicine.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters) |
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UniBasel Contributors: | Pieters, Jean |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Lippincott Williams & Wilkins |
ISSN: | 0041-1337 |
e-ISSN: | 1534-6080 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 03 Jul 2023 10:26 |
Deposited On: | 13 Apr 2020 12:52 |
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