edoc

Induction of allograft tolerance while maintaining immunity against microbial pathogens: does coronin 1 hold a key?

Jayachandran, Rajesh and Pieters, Jean. (2019) Induction of allograft tolerance while maintaining immunity against microbial pathogens: does coronin 1 hold a key? Transplantation, in press. pp. 1-28.

[img] PDF - Accepted Version
Restricted to Repository staff only

992Kb

Official URL: https://edoc.unibas.ch/74803/

Downloads: Statistics Overview

Abstract

Selective suppression of graft rejection while maintaining anti-pathogen responses has been elusive. Thus far, the most successful strategies to induce suppression of graft rejection relies on inhibition of T cell activation. However, the very same mechanisms that induce allograft-specific T cell suppression are also important for immunity against microbial pathogens as well as oncogenically transformed cells, resulting in significant immunosuppression-associated comorbidities. Therefore, defining the pathways that differentially regulate anti-graft versus anti-microbial T cell responses may allow the development of regimen to induce allograft-specific tolerance. Recent work has defined a molecular pathway driven by the immunoregulatory protein coronin 1 that regulates the phosphodiesterase/cAMP pathway and modulates T cell responses. Interestingly, disruption of coronin 1 promotes allograft tolerance while immunity towards a range of pathogenic microbes is maintained. Here, we briefly review the work leading up to these findings as well as their possible implications for transplantation medicine.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
ISSN:0041-1337
e-ISSN:1534-6080
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:13 Apr 2020 12:52
Deposited On:13 Apr 2020 12:52

Repository Staff Only: item control page