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The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex

Bianco, Isaac H. and Ma, Leung-Hang and Schoppik, David and Robson, Drew N. and Orger, Michael B. and Beck, James C. and Li, Jennifer M. and Schier, Alexander F. and Engert, Florian and Baker, Robert. (2012) The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex. Current Biology, 22 (14). pp. 1285-1295.

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Official URL: https://edoc.unibas.ch/74703/

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Abstract

Although adult vertebrates sense changes in head position by using two classes of accelerometer, at larval stages zebrafish lack functional semicircular canals and rely exclusively on their otolithic organs to transduce vestibular information.; Despite this limitation, we find that larval zebrafish perform an effective vestibulo-ocular reflex (VOR) that serves to stabilize gaze in response to pitch and roll tilts. By using single-cell electroporations and targeted laser ablations, we identified a specific class of central vestibular neurons, located in the tangential nucleus, that are essential for the utricle-dependent VOR. Tangential nucleus neurons project contralaterally to extraocular motoneurons and in addition to multiple sites within the reticulospinal complex.; We propose that tangential neurons function as a broadband inertial accelerometer, processing utricular acceleration signals to control the activity of extraocular and postural neurons, thus completing a fundamental three-neuron circuit responsible for gaze stabilization.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
ISSN:0960-9822
e-ISSN:1879-0445
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Nov 2021 15:04
Deposited On:23 Nov 2021 15:04

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