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Response to Nodal morphogen gradient is determined by the kinetics of target gene induction

Dubrulle, Julien and Jordan, Benjamin M. and Akhmetova, Laila and Farrell, Jeffrey A. and Kim, Seok-Hyung and Solnica-Krezel, Lilianna and Schier, Alexander F.. (2015) Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. eLife, 4. e05042.

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Official URL: https://edoc.unibas.ch/74686/

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Abstract

Morphogen gradients expose cells to different signal concentrations and induce target genes with different ranges of expression. To determine how the Nodal morphogen gradient induces distinct gene expression patterns during zebrafish embryogenesis, we measured the activation dynamics of the signal transducer Smad2 and the expression kinetics of long- and short-range target genes. We found that threshold models based on ligand concentration are insufficient to predict the response of target genes. Instead, morphogen interpretation is shaped by the kinetics of target gene induction: the higher the rate of transcription and the earlier the onset of induction, the greater the spatial range of expression. Thus, the timing and magnitude of target gene expression can be used to modulate the range of expression and diversify the response to morphogen gradients.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:eLife Sciences Publications
ISSN:2050-084X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:26 May 2020 15:56
Deposited On:26 May 2020 15:56

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