Stellate cells drive maturation of the entorhinal-hippocampal circuit

Donato, Flavio and Jacobsen, R. Irene and Moser, May-Britt and Moser, Edvard I.. (2017) Stellate cells drive maturation of the entorhinal-hippocampal circuit. Science, 355 (6330). eaai8178.

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Official URL: https://edoc.unibas.ch/74488/

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The neural representation of space relies on a network of entorhinal-hippocampal cell types with firing patterns tuned to different abstract features of the environment. To determine how this network is set up during early postnatal development, we monitored markers of structural maturation in developing mice, both in naïve animals and after temporally restricted pharmacogenetic silencing of specific cell populations. We found that entorhinal stellate cells provide an activity-dependent instructive signal that drives maturation sequentially and unidirectionally through the intrinsic circuits of the entorhinal-hippocampal network. The findings raise the possibility that a small number of autonomously developing neuronal populations operate as intrinsic drivers of maturation across widespread regions of the cortex.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Neurobiology (Donato)
UniBasel Contributors:Donato, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Mar 2020 18:13
Deposited On:29 Mar 2020 18:13

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