edoc

An Interlaminotomy New Zealand White Rabbit Model to Evaluate Novel Epidural Strategies

Nevzati, Edin and Soleman, Jehuda and Schöpf, Salome Aglaia and Coluccia, Daniel and Fandino, Javier and Marbacher, Serge. (2015) An Interlaminotomy New Zealand White Rabbit Model to Evaluate Novel Epidural Strategies. Journal of neurological surgery. Part A, Central European neurosurgery, 76 (6). pp. 466-472.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/74443/

Downloads: Statistics Overview

Abstract

OBJECTIVE: The New Zealand White (NZW) rabbit model is an established animal model for examining surgical methods to prevent epidural scar formation after spine surgery. As most approaches include complete laminectomy of the rabbit vertebra, this procedure is associated with high morbidity and mortality rates. We examined a less invasive technique, the microsurgical interlaminotomy, for testing epidural substance application in the rabbit spine. METHODS: Surgery was performed in the cadaver rabbit spine to evaluate the approach before performing it in NZW rabbits. All surgical procedures were performed under an operation microscope. Female rabbits with a mean weight of 4770âEuro‰gâEuro‰ ± âEuro‰240âEuro‰g were used. Neurologic symptoms were analyzed based on predefined scores. After resection of the spinal process, the caudal part of the upper lamina was resected using a drill and a 1-mm Kerrison punch. The yellow ligament was resected resulting in a dural exposure of ∼ 5âEuro‰Ã-âEuro‰10 mm. RESULTS: Eight pilot interlaminotomies were performed on three cadaveric spines to establish the surgical approach. Twenty-one NZW rabbits were then operated on using the interlaminotomy model. Three rabbits (14.3%) died during surgery due to anesthesia-related complications. Two rabbits (9.5%) showed partial paresis of the lower extremities and one (4.8%) a complete paraplegia. The remaining 15 rabbits (71.4%) had an uneventful recovery without neurologic symptoms. The mean surgical duration was 88 +/- 28 minutes. CONCLUSION: The rabbit interlaminotomy model is associated with few neurologic deficits and a relatively short operating time.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Kopfbereich > Neurochirurgie (Guzman)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Kopfbereich > Neurochirurgie (Guzman)
03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Kopfbereich > Neurochirurgie (Mariani)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Kopfbereich > Neurochirurgie (Mariani)
UniBasel Contributors:Soleman, Jehuda
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Thieme
ISSN:2193-6315
e-ISSN:2193-6323
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:29 Sep 2020 10:48
Deposited On:29 Sep 2020 10:48

Repository Staff Only: item control page