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An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

Wong, Ting Yat and Radua, Joaquim and Pomarol-Clotet, Edith and Salvador, Raymond and Albajes-Eizagirre, Anton and Solanes, Aleix and Canales-Rodriguez, Erick J. and Guerrero-Pedraza, Amalia and Sarro, Salvador and Kircher, Tilo and Nenadic, Igor and Krug, Axel and Grotegerd, Dominik and Dannlowski, Udo and Borgwardt, Stefan and Riecher-Rössler, Anita and Schmidt, Andre and Andreou, Christina and Huber, Christian G. and Turner, Jessica and Calhoun, Vince and Jiang, Wenhao and Clark, Sarah and Walton, Esther and Spalletta, Gianfranco and Banaj, Nerisa and Piras, Fabrizio and Ciullo, Valentina and Vecchio, Daniela and Lebedeva, Irina and Tomyshev, Alexander S. and Kaleda, Vasily and Klushnik, Tatyana and Filho, Geraldo Busatto and Zanetti, Marcus Vinicius and Serpa, Mauricio Henriques and Penteado Rosa, Pedro Gomes and Hashimoto, Ryota and Fukunaga, Masaki and Richter, Anja and Krämer, Bernd and Gruber, Oliver and Voineskos, Aristotle N. and Dickie, Erin W. and Tomecek, David and Skoch, Antonin and Spaniel, Filip and Hoschl, Cyril and Bertolino, Alessandro and Bonvino, Aurora and Di Giorgio, Annabella and Holleran, Laurena and Ciufolini, Simone and Marques, Tiago Reis and Dazzan, Paola and Murray, Robin and Lamsma, Jelle and Cahn, Wiepke and van Haren, Neeltje and Díaz-Zuluaga, Ana M. and Pineda-Zapata, Julián A. and Vargas, Cristian and López-Jaramillo, Carlos and van Erp, Theo G. M. and Gur, Ruben C. and Nickl-Jockschat, Thomas. (2019) An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium. Psychological medicine. pp. 1-12.

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Official URL: https://edoc.unibas.ch/73883/

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Abstract

Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.; To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.; The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.; These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Schmidt, André
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1469-8978
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Aug 2020 07:42
Deposited On:19 Aug 2020 07:42

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