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Common brain disorders are associated with heritable patterns of apparent aging of the brain

Kaufmann, Tobias and van der Meer, Dennis and Doan, Nhat Trung and Schwarz, Emanuel and Lund, Martina J. and Agartz, Ingrid and Alnæs, Dag and Barch, Deanna M. and Baur-Streubel, Ramona and Bertolino, Alessandro and Bettella, Francesco and Beyer, Mona K. and Bøen, Erlend and Borgwardt, Stefan and Brandt, Christine L. and Buitelaar, Jan and Celius, Elisabeth G. and Cervenka, Simon and Conzelmann, Annette and Córdova-Palomera, Aldo and Dale, Anders M. and de Quervain, Dominique J. F. and Di Carlo, Pasquale and Djurovic, Srdjan and Dørum, Erlend S. and Eisenacher, Sarah and Elvsåshagen, Torbjørn and Espeseth, Thomas and Fatouros-Bergman, Helena and Flyckt, Lena and Franke, Barbara and Frei, Oleksandr and Haatveit, Beathe and Håberg, Asta K. and Harbo, Hanne F. and Hartman, Catharina A. and Heslenfeld, Dirk and Hoekstra, Pieter J. and Høgestøl, Einar A. and Jernigan, Terry L. and Jonassen, Rune and Jönsson, Erik G. and Karolinska Schizophrenia Project, and Kirsch, Peter and Kłoszewska, Iwona and Kolskår, Knut K. and Landrø, Nils Inge and Le Hellard, Stephanie and Lesch, Klaus-Peter and Lovestone, Simon and Lundervold, Arvid and Lundervold, Astri J. and Maglanoc, Luigi A. and Malt, Ulrik F. and Mecocci, Patrizia and Melle, Ingrid and Meyer-Lindenberg, Andreas and Moberget, Torgeir and Norbom, Linn B. and Nordvik, Jan Egil and Nyberg, Lars and Oosterlaan, Jaap and Papalino, Marco and Papassotiropoulos, Andreas and Pauli, Paul and Pergola, Giulio and Persson, Karin and Richard, Geneviève and Rokicki, Jaroslav and Sanders, Anne-Marthe and Selbæk, Geir and Shadrin, Alexey A. and Smeland, Olav B. and Soininen, Hilkka and Sowa, Piotr and Steen, Vidar M. and Tsolaki, Magda and Ulrichsen, Kristine M. and Vellas, Bruno and Wang, Lei and Westman, Eric and Ziegler, Georg C. and Zink, Mathias and Andreassen, Ole A. and Westlye, Lars T.. (2019) Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience, 22 (10). pp. 1617-1623.

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Official URL: https://edoc.unibas.ch/73740/

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Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
UniBasel Contributors:Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature America
ISSN:1097-6256
e-ISSN:1546-1726
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Sep 2020 08:30
Deposited On:13 Jul 2020 13:30

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