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Deworming children for soil-transmitted helminths in low and middle-income countries: systematic review and individual participant data network meta-analysis

Welch, A. V. and Hossain, A. and Ghogomu, E. and Riddle, A. and Cousens, S. and Gaffey, M. and Arora, P. and Black, R. E. and Bundy, D. A. P. and Castro, M. and Chen, L. and Dewidar, O. and Elliott, A. and Friis, H. and Hollingsworth, T. D. and Horton, S. and King, C. H. and Thi, H. L. and Liu, C. and Rohner, F. and Rousham, E. K. and Salam, R. and Sartono, E. and Steinmann, P. and Supali, T. and Tugwell, P. and Webb, E. and Wieringa, E. and Winnichagoon, P. and Yazdanbakhsh, M. and Bhutta, Z. A. and Wells, G. A.. (2019) Deworming children for soil-transmitted helminths in low and middle-income countries: systematic review and individual participant data network meta-analysis. Journal of Development Effectiveness, 11 (3). pp. 288-306.

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Official URL: https://edoc.unibas.ch/73498/

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Abstract

Intestinal parasites affect millions of children globally. We aimed to assess effects of deworming children on nutritional and cognitive outcomes across potential effect modifiers using individual participant data (IPD). We searched multiple databases to 27 March 2018, grey literature, and other sources. We included randomised and quasi randomised trials of deworming compared to placebo or other nutritional interventions with data on baseline infection. We used a random-effects network meta-analysis with IPD and assessed overall quality, following a pre-specified protocol. We received IPD from 19 trials of STH deworming. Overall risk of bias was low. There were no statistically significant subgroup effects across age, sex, nutritional status or infection intensity for each type of STH. These analyses showed that children with moderate or heavy intensity infections, deworming for STH may increase weight gain (very low certainty). The added value of this review is an exploration of effects on growth and cognition in children with moderate to heavy infections as well as replicating prior systematic review results of small effects at the population level. Policy implications are that complementary public health strategies need to be assessed and considered to achieve growth and cognition benefits for children in helminth endemic areas.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Swiss Centre for International Health (SCIH) > Health Systems Support (Prytherch)
UniBasel Contributors:Steinmann, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Routledge, Taylor & Francis Group
ISSN:1943-9342
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 Mar 2020 14:13
Deposited On:03 Mar 2020 14:13

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