Low-dose cortisol for symptoms of posttraumatic stress disorder

Aerni, Amanda and Traber, Rafael and Hock, Christoph and Roozendaal, Benno and Schelling, Gustav and Papassotiropoulos, Andreas and Nitsch, Roger M. and Schnyder, Ulrich and de Quervain, Dominique J.-F.. (2004) Low-dose cortisol for symptoms of posttraumatic stress disorder. American Journal of Psychiatry, Vol. 161, H. 8. pp. 1488-1490.

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Official URL: http://edoc.unibas.ch/dok/A5257176

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OBJECTIVE: Because elevated cortisol levels inhibit memory retrieval in healthy human subjects, the present study investigated whether cortisol administration might also reduce excessive retrieval of traumatic memories and related symptoms in patients with chronic posttraumatic stress disorder (PTSD). METHOD: During a 3-month observation period, low-dose cortisol (10 mg/day) was administered orally for 1 month to three patients with chronic PTSD in a double-blind, placebo-controlled, crossover design. RESULTS: In each patient investigated, there was a significant treatment effect, with cortisol-related reductions of at least 38% in one of the daily rated symptoms of traumatic memories, as assessed by self-administered rating scales. In accordance, Clinician-Administered PTSD Scale ratings assessed after each month showed cortisol-related improvements for reexperiencing symptoms and, additionally, in one patient for avoidance symptoms. CONCLUSIONS: The results of this pilot study indicate that low-dose cortisol treatment reduces the cardinal symptoms of PTSD.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Molecular Neuroscience (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:American Psychiatric Association
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:23 Nov 2017 08:41
Deposited On:22 Mar 2012 13:38

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