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Membrane and soluble protein structure determination by cryo-TEM

Adaixo, Ricardo Jorge Diogo. Membrane and soluble protein structure determination by cryo-TEM. 2019, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_13505

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Abstract

Proteins are biological polymers ubiquitous through all forms of life. Essential processes such as ion conduction, enzymatic catalysis, signal detection and transduction rely on proteins. Structural aspects of the cell such as the cell shape or the compact packing of DNA in a chromosome also require proteins.
While DNA carries the genetic information, which ultimately defines the response of a cell to any given event, virtually all processes in the cell depend on proteins to occur.
In this thesis cryogenic electron microscopy and single particle analysis workflow are used to determine electron density maps of a set of both soluble and membrane proteins. The obtained structural information is used to elucidate biological processes of the analysed proteins therefore linking structure to function.
Advisors:Stahlberg, Henning and Abrahams, Jan Pieter
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Stahlberg)
UniBasel Contributors:Stahlberg, Henning and Abrahams, Jan Pieter
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:13505
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (155 Seiten)
Language:English
Identification Number:
Last Modified:19 Feb 2020 05:30
Deposited On:18 Feb 2020 15:07

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