Havet, Anaïs and Li, Zhen and Zerimech, Farid and Sanchez, Margaux and Siroux, Valérie and Le Moual, Nicole and Brunekreef, Bert and Künzli, Nino and Jacquemin, Bénédicte and Varraso, Raphaëlle and Matran, Régis and Nadif, Rachel. (2019) Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study. Environmental health, 18. p. 90.
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Abstract
Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma.; Analyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003-2007) and EGEA3 (follow-up, 2011-2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM; 10; ) and ≤ 2.5 μm were estimated by ESCAPE models (2009-2010), and ozone (O; 3; ) by IFEN models (2004). We used a mediation analysis to assess the mediated effect by FlOPs levels and the interaction between FlOPs levels and air pollution.; FlOPs levels increased with PM; 10; and O; 3; (adjusted β = 0.04 (95%CI 0.001-0.08), aβ = 0.04 (95%CI 0.009-0.07) per 10 μg/m; 3; , respectively), and the risk of persistent asthma increased with FlOPs levels (aOR = 1.81 (95%CI 1.08-3.02)). The risk of persistent asthma decreased with exposures to NO; 2; , NOx and PM; 2.5; (aOR ranging from 0.62 to 0.94), and increased with exposures to PM; 10; , O; 3; , O; 3-summer; and road traffic, the greater effect being observed for O; 3; (aOR = 1.78, 95% CI 0.73-4.37, per 10 μg/m; 3; ). Using mediation analysis, we observed a positive total effect (aOR = 2.16, 95%CI 0.70-11.9), a positive direct effect of O; 3; on persistent asthma (OR = 1.68, 95%CI 0.57-7.25), and a positive indirect effect mediated by FIOPs levels (aOR = 1.28 (95%CI 1.01-2.29)) accounting for 41% of the total effect.; Our results add insights on the role of oxidative stress in the association between air pollution and persistent asthma.
Faculties and Departments: | 03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Air Pollution and Health (Künzli) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) |
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UniBasel Contributors: | Künzli, Nino |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | BioMed Central |
ISSN: | 1476-069X |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 02 Dec 2019 10:59 |
Deposited On: | 02 Dec 2019 10:59 |
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