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Polymer Nanocontainers for Drug Delivery

Sauer, Marc and Graff, A. and Meier, Wolfgang. (2004) Polymer Nanocontainers for Drug Delivery. In: Carrier-Based Drug Delivery. Oxford University Press, pp. 224-237.

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Official URL: https://edoc.unibas.ch/72759/

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Abstract

Vesicle-templated nanocontainers prepared from ABA triblock copolymers possess great potential for applications in areas such as drug delivery or pharmacology. For example, PMOXA-PDMS-PMOXA copolymers self-aggregate in water to form vesicles in a size range from 50 nm up to 100 μm. Intravesicular crosslinking of polymerizable end groups transforms the vesicles into solid-like nanocontainers. The permeability of these nanocontainers can be controlled either by attachment of stimuli-responsive groups or by reconstitution of membrane proteins within the container shells. These functionalizations can be used to prepare responsive load-and-release systems and biomimetic hybrid materials such as responsive nanoreactors or DNA-loaded nanoparticles with outstanding properties. Potential applications such as enzyme encapsulation and gene transfection will be discussed and illustrated using model systems.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
ISBN:978-0-8412-3839-8
e-ISBN:978-0-8412-1984-7
Series Name:ACS Symposium Series
Issue Number:879
Note:Publication type according to Uni Basel Research Database: Book item
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Last Modified:18 Mar 2020 16:34
Deposited On:18 Mar 2020 16:34

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