Broz, Pavel and Driamov, Sergey and Ziegler, Joerg and Ben-Haim, Nadav and Marsch, Stephan and Meier, Wolfgang and Hunziker, Patrick. (2006) Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer. Nano Letters, 6 (10). pp. 2349-2353.
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Official URL: https://edoc.unibas.ch/72418/
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Abstract
To develop an intelligent sensorâˆ'effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4âˆ'6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie 05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier) |
|---|---|
| UniBasel Contributors: | Meier, Wolfgang P. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Chemical Society |
| ISSN: | 1530-6984 |
| e-ISSN: | 1530-6992 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
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| Last Modified: | 18 Mar 2020 15:02 |
| Deposited On: | 18 Mar 2020 15:02 |
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