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Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer

Broz, Pavel and Driamov, Sergey and Ziegler, Joerg and Ben-Haim, Nadav and Marsch, Stephan and Meier, Wolfgang and Hunziker, Patrick. (2006) Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer. Nano Letters, 6 (10). pp. 2349-2353.

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Official URL: https://edoc.unibas.ch/72418/

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Abstract

To develop an intelligent sensorâˆ'effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4âˆ'6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1530-6984
e-ISSN:1530-6992
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Mar 2020 15:02
Deposited On:18 Mar 2020 15:02

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