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Cell Targeting by a Generic Receptor-programmable Polymer Nanocontainer Platform

Broz, Pavel and Benito, Samantha Mariela and Saw, CheeLoong and Burger, Peter and Heider, Harald and Pfisterer, Matthias and Marsch, Stephan and Meier, Wolfgang and Hunziker, Patrick. (2005) Cell Targeting by a Generic Receptor-programmable Polymer Nanocontainer Platform. Journal of Controlled Release, 102 (2). pp. 475-488.

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Official URL: https://edoc.unibas.ch/72410/

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Abstract

Nanotechnology promises new avenues to medical diagnosis and treatment. Of special interest are injectable nanovehicles that are programmable towards specific targets, are able to evade the immune defense, and are versatile enough to be suited as carriers of complex functionality. Biotin-functionalized (poly(2-methyloxazoline)–b-poly(dimethylsiloxane)–b-poly(2-methyloxazoline) triblock copolymers were self-assembled to form nanocontainers, and biotinylated targeting ligands were attached by using streptavidin as a coupling agent. Specifically, fluorescence-labeled nanocontainers were targeted against the scavenger receptor A1 from macrophages, an important cell in human disease. In human and transgenic cell lines and in mixed cultures, receptor-specific binding of these generic carriers was followed by vesicular uptake. Low nonspecific binding supported the “stealth” properties of the carrier while cytotoxicity was absent. This versatile carrier appears promising for diagnostic or therapeutic medical use.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0168-3659
e-ISSN:1873-4995
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Mar 2020 14:50
Deposited On:18 Mar 2020 14:50

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