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Liposome-based nanocapsules

Ruysschaert, T. and Germain, M. and Da Silva Gomes, J.F.P. and Fournier, D. and Sukhorukov, G. B. and Meier, W. and Winterhalter, M.. (2004) Liposome-based nanocapsules. IEEE Transactions on NanoBioscience, 3 (1). pp. 49-55.

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Official URL: https://edoc.unibas.ch/72405/

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Abstract

Here we present three different types of mechanically stable nanometer-sized hollow capsules. The common point of the currently developed systems in our laboratory is that they are liposome based. Biomolecules can be used to functionalize lipid vesicles to create a new type of intelligent material. For example, insertion of membrane channels into the capsule wall can modify the permeability. Covalent binding of antibodies allows targeting of the capsule to specific sites. Liposomes loaded with enzymes may provide an optimal environment for them with respect to the maximal turnover and may stabilize the enzyme. However, the main drawback of liposomes is their instability in biological media as well as their sensitivity to many external parameters such as temperature or osmotic pressure. To increase their stability we follow different strategies: 1) polymerize a two-dimensional network in the hydrophobic core of the membrane; 2) coat the liposome with a polyelectrolyte shell; or 3) add surface active polymers to form mixed vesicular structures.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Institute of Electrical and Electronics Engineers
ISSN:1536-1241
e-ISSN:1558-2639
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:18 Mar 2020 15:22
Deposited On:18 Mar 2020 15:22

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