Hybrid Materials from Amphiphilic Block Copolymers and Membrane Proteins

Nardin, Corinne and Meier, Wolfgang. (2002) Hybrid Materials from Amphiphilic Block Copolymers and Membrane Proteins. Reviews in Molecular Biotechnology, 90 (1). pp. 17-26.

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Self-assembly of reactive amphiphilic block copolymers is used to prepare nanostructured hydrogels with exceptional permeability properties, vesicular structures and planar, freestanding membranes in aqueous solution. Although the underlying block copolymer membranes are two–three-fold thicker than conventional lipid bilayers, they can be regarded as mimetic of biological membranes and can be used as a matrix for membrane-spanning proteins. Surprisingly, the proteins remain functional, despite the extreme thickness of the membranes and even after polymerization of the reactive block copolymers. The unique combination of block copolymers with membrane proteins allows the preparation of mechanically stable, defect-free membranes and nanocapsules that have highly selective permeability and/or specific recognition sites. This is documented by some representative examples.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Mar 2020 09:02
Deposited On:19 Mar 2020 09:02

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