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Stabilization of planar lipid membranes: A stratified layer approach

Meier, Wolfgang and Alexandra, Graff and Diederich, Anke and Winterhalter, Mathias. (2000) Stabilization of planar lipid membranes: A stratified layer approach. Physical Chemistry Chemical Physics, 2 (20). pp. 4559-4562.

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Official URL: https://edoc.unibas.ch/72385/

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Abstract

Here we briefly summarize our recent efforts in stabilization of giant planar lipid membranes and provide the first promising results achieved with a new technique. A water-soluble polymer can be coupled to lipid membranes either electrostatically or via a hydrophobic linker. Such coated membranes are significantly destabilized and the rupture process is slowed down. In contrast, partitioning of hydrophobic styrene monomer into the lipid membrane and its polymerization lead to an increase in stability. A short electric field pulse under controlled conditions was applied to quantify the stability. Voltages above 1.2 V are required to induce an electrical discharge. Within less than 100 mu s these defects reseal. However, after resealing, the stability of this particular lipid membrane corresponds to that of a lipid membrane without a 2-D polymer network. We suggest the use of this technique to stabilize self-assembled lipid membrane structures.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:1463-9076
e-ISSN:1463-9084
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:19 Mar 2020 14:47
Deposited On:19 Mar 2020 14:47

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