Neue Möglichkeiten in der Therapie der hepatischen Enzephalopathie?

Meier, P. J. and Bansky, G.. (1990) Neue Möglichkeiten in der Therapie der hepatischen Enzephalopathie? Schweizerische medizinische Wochenschrift, Jg. 120, Nr. 15. pp. 553-556.

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Official URL: http://edoc.unibas.ch/dok/A5261775

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Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome associated with acute or chronic liver disease. It is generally considered a metabolic and potentially reversible syndrome. An important component of HE is increased neuro-inhibition caused by reduced hepatic metabolism of gut-derived nitrogenous substances and by activation of the postsynaptic GABAA-receptor complex in the central nervous system. Effective conventional therapy of HE includes prevention of precipitating factors, restriction of dietary protein an administration of lactulose (or lactitol) and possibly also of antibiotics. In addition, animal studies and uncontrolled clinical studies indicate that the benzodiazepine antagonist flumazenil effectively diminishes the increased neuroinhibition in certain patients with HE. However, these favourable flumazenil effects must be confirmed in larger randomized and placebo-controlled multicenter studies before flumazenil can be regarded as a useful new addition to current management of patients with acute or chronic hepatic encephalopathy.
Faculties and Departments:11 Rektorat und Verwaltung > Vizerektorat Forschung
UniBasel Contributors:Meier-Abt, Peter J.
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:Benno Schwabe
Note:Note: Standartisierter englischer Titel: Current possibilities in the therapy of hepatic encephalopathy -- Note: Summary in english -- Publication type according to Uni Basel Research Database: Journal item
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:38

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