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A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles

Stress, Cedric J. and Sauter, Basilius and Schneider, Lukas A. and Sharpe, Timothy and Gillingham, Dennis. (2019) A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles. Angewandte Chemie International Edition, 58 (28). pp. 9570-9574.

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Abstract

Abstract Here we show a seven-step chemical synthesis of a DNA-encoded macrocycle library (DEML) on DNA. Inspired by polyketide and mixed peptide-polyketide natural products, the library was designed to incorporate rich backbone diversity. Achieving this diversity, however, comes at the cost of the custom synthesis of bifunctional building block libraries. This study outlines the importance of careful retrosynthetic design in DNA-encoded libraries, while revealing areas where new DNA synthetic methods are needed.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Gillingham)
UniBasel Contributors:Sauter, Basilius and Schneider, Lukas and Stress, Cedric and Sharpe, Timothy and Gillingham, Dennis
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1433-7851
e-ISSN:1521-3773
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:29 Oct 2019 12:17
Deposited On:29 Oct 2019 12:17

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