Changing Trends in International Versus Domestic HCV Transmission in HIV-Positive Men Who Have Sex With Men: A Perspective for the Direct-Acting Antiviral Scale-Up Era

Salazar-Vizcaya, Luisa and Kouyos, Roger D. and Metzner, Karin J. and Cortes, Kamila Caraballo and Boni, Jurg and Shah, Cyril and Fehr, Jan and Braun, Dominique L. and Bernasconi, Enos and Mbunkah, Herbert A. and Hoffmann, Matthias and Labhardt, Niklaus and Cavassini, Matthias and Rougemont, Mathieu and Gunthard, Huldrych F. and Keiser, Olivia and Rauch, Andri and Aubert, V. and Battegay, M. and Bernasconi, E. and Boni, J. and Braun, D. L. and Bucher, H. C. and Calmy, A. and Cavassini, M. and Ciuffi, A. and Dollenmaier, G. and Egger, M. and Elzi, L. and Fehr, J. and Fellay, J. and Furrer, H. and Fux, C. A. and Gunthard, H. F. and Haerry, D. and Hasse, B. and Hirsch, H. H. and Hoffmann, M. and Hosli, I. and Kahlert, C. and Kaiser, L. and Keiser, O. and Klimkait, T. and Kouyos, R. D. and Kovari, H. and Ledergerber, B. and Martinetti, G. and de Tejada, Martinez B. and Marzolini, C. and Metzner, K. J. and Mueller, N. and Nicca, D. and Pantaleo, G. and Paioni, P. and Rauch, A. and Rudin, C. and Scherrer, A. U. and Schmid, P. and Speck, R. and Stockle, M. and Tarr, P. and Trkola, A. and Vernazza, P. and Wandeler, G. and Weber, R. and Yerly, S. and Swiss HIV Cohort Study, . (2019) Changing Trends in International Versus Domestic HCV Transmission in HIV-Positive Men Who Have Sex With Men: A Perspective for the Direct-Acting Antiviral Scale-Up Era. Journal of Infectious Diseases, 220 (1). pp. 91-99.

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Background. Scale-up of direct-acting antiviral therapy is expected to abate hepatitis C virus (HCV) incidence among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). International transmission could influence this process. We classified HCV infections in HIV-positive MSM as either domestically or internationally acquired, and estimated how this classification changed over time.Methods. HCV subtype 1a (the most frequent subtype among MSM) genomes from 99 persons enrolled in the Swiss HIV Cohort Study and diagnosed with replicating HCV infections, were sequenced. Sixty-six of these sequences were from MSM. We inferred maximum-likelihood phylogenetic trees and time trees containing a fragment of the NS5B region of these and 374 circulating strains. We inferred transmission clusters from these trees and used the country composition of such clusters to attribute infections to domestic or international transmission.Results. Of HCV transmissions, 50% to 80% were classified as domestic depending on the classification criterion. Between 2000 and 2007, the fraction attributable to domestic transmission was 54% (range 0%-75%). It increased to 85% (range 67%-100%) between 2008 and 2016.Conclusions. International and domestic transmission have played major roles in this epidemic. While international transmission persists, local transmission has established as the main source of infections.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft
03 Faculty of Medicine > Departement Public Health > Ehemalige Einheiten Public Health > Pflegewissenschaft (Nicca)
UniBasel Contributors:Nicca, Dunja
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Jul 2020 12:47
Deposited On:10 Jul 2020 12:47

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