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A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab; ®;

Stader, Felix and Penny, Melissa A. and Siccardi, Marco and Marzolini, Catia. (2019) A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab; ®;. CPT: Pharmacometrics & Systems Pharmacology, 8 (7). pp. 444-459.

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Official URL: https://edoc.unibas.ch/72248/

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Abstract

Physiologically based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole-body PBPK model in Matlab; ®; to answer specific pharmacological questions involving drug disposition, and magnitudes of drug-drug interactions in different patient populations. This article is protected by copyright. All rights reserved.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M)
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:2163-8306
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Jul 2020 12:01
Deposited On:10 Jul 2020 12:01

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