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Higher pulmonary artery pressure in children than in adults upon fast ascent to high altitude

Kriemler, S. and Jansen, C. and Linka, A. and Kessel-Schaefer, A. and Zehnder, M. and Schürmann, T. and Kohler, M. and Bloch, K. and Brunner-La Rocca, H. P.. (2008) Higher pulmonary artery pressure in children than in adults upon fast ascent to high altitude. The European respiratory journal, Vol. 32, H. 3. pp. 664-669.

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Official URL: http://edoc.unibas.ch/dok/A5253319

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Abstract

The response of pulmonary artery pressure to high altitude has not been studied in children. It is also not known whether the individual response is hereditary. Therefore, the response of pulmonary artery pressure to high altitude was measured in pre-pubertal children in comparison to that in their biological fathers. Echocardiography was performed at 450 m and over 3 days at 3,450 m. Systolic pulmonary artery pressure was estimated from the pressure gradient of tricuspid regurgitation. The increase in pulmonary artery pressure in children was greater than that in adults at day 1 of high altitude (15.5+/-9.1 versus 7.9+/-6.4 mmHg), but returned to adult levels on day 2. The increase in pulmonary artery pressure from low to high altitude of each child correlated with that in the father. Pre-pubertal children transiently develop greater pulmonary hypertension than their fathers when exposed to high altitude. The individual response of pulmonary pressure to high altitude seems to be at least partly hereditary.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Sportmedizin (Schmidt-Trucksäss)
UniBasel Contributors:Kriemler, Susi and Brunner, Hanspeter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Dec 2012 13:00
Deposited On:22 Mar 2012 13:38

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