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Children at high altitude have less nocturnal periodic breathing than adults

Kohler, M. and Kriemler, S. and Wilhelm, E. M. and Brunner-LaRocca, H. and Zehnder, M. and Bloch, K. E.. (2008) Children at high altitude have less nocturnal periodic breathing than adults. The European respiratory journal, Vol. 32, H. 1. pp. 189-197.

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Official URL: http://edoc.unibas.ch/dok/A5253321

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Abstract

Although children commonly travel to high altitudes, their respiratory adaptation to hypoxia remains elusive. Therefore, in the present study respiratory inductive plethysmography, pulse oximetry (S(p,O(2))) and end-tidal CO(2) tension (P(ET,CO(2))) were recorded in 20 pre-pubertal children (aged 9-12 yrs) and their fathers during 1 night in Zurich (490 m) and 2 nights at the Swiss Jungfrau-Joch research station (3,450 m) following ascent by train within >3 h. In children, mean±sd nocturnal Sp,O2 fell from 98±1% at 490 m to 85±4 and 86±4% at 3,450 m (nights 1 and 2, respectively); PET,CO2decreased significantly from 37±6 to 32±3 and 33±4 mmHg (3,450 versus 490 m). In adults, changes in nocturnal Sp,O2 and PET,CO2at 3,450 m were similar to those in children. Children spent less time in periodic breathing at 3,450 m during night 1 and 2 (8±11 and 9±13%, respectively) than adults (34±24 and 22±17%, respectively), and their apnoea threshold for CO2 was lower compared with adults (27±2 and 30±2 mmHg, respectively, both nights). Sp,O2, PET,CO2 and time in periodic breathing at altitude were not correlated between children and their fathers. In conclusion, children revealed a similarly reduced nocturnal O2 saturation and associated hyperventilation at high altitude as adults but their breathing pattern was more stable, possibly related to a lower apnoea threshold for CO2.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Sportmedizin (Schmidt-Trucksäss)
UniBasel Contributors:Kriemler, Susi and Brunner, Hanspeter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:13
Deposited On:22 Mar 2012 13:38

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