The transferability of lipid loci across African, Asian and European cohorts

Kuchenbaecker, Karoline and Telkar, Nikita and Reiker, Theresa and Walters, Robin G. and Lin, Kuang and Eriksson, Anders and Gurdasani, Deepti and Gilly, Arthur and Southam, Lorraine and Tsafantakis, Emmanouil and Karaleftheri, Maria and Seeley, Janet and Kamali, Anatoli and Asiki, Gershim and Millwood, Iona Y. and Holmes, Michael and Du, Huaidong and Guo, Yu and Kumari, Meena and Dedoussis, George and Li, Liming and Chen, Zhengming and Sandhu, Manjinder S. and Zeggini, Eleftheria and Understanding Society Scientific Group, . (2019) The transferability of lipid loci across African, Asian and European cohorts. Nature Communications, 10. p. 4330.

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Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23-0.28, p < 1.9 × 10; -14; ). Overall, there is evidence of reproducibility for ~75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan samples (10% of loci). Individual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Household Economics and Health Systems Research > Epidemiology and Household Economics (Fink)
06 Faculty of Business and Economics > Departement Wirtschaftswissenschaften > Professuren Wirtschaftswissenschaften > Epidemiology and Household Economics (Fink)
UniBasel Contributors:Reiker, Theresa
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Sep 2019 07:49
Deposited On:30 Sep 2019 07:49

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